MS9715 Datasheet DC Chemicals

Description	MS9715 (MS-9715) is a NSD3-targeting PROTAC designed by linking BI-9321, a NSD3 antagonist, which binds NSD3's PWWP1 domain, with an E3 ligase VHL ligand.MS9715 achieves effective and specific targeting of NSD3 and associated cMyc node in tumor cells.MS9715 effectively suppresses growth of NSD3-dependent hematological cancer cells.MS 9715 effectively suppresses NSD3-and cMyc-associated gene expression programs, resembling effects of the CRISPR-Cas9-mediated knockout of NSD3.
Cat.No	DC70621
Name	MS9715

Chemical Properties

CAS
Formula	C58H74FN9O5S
MW	1028.346
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

1. Chenxi Xu, et al. Cell Chem Biol. 2021 Aug 30;S2451-9456(21)00393-7.

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