MS9715|PROTACS |DC Chemicals

Cas No.:
Chemical Name:	MS9715
Synonyms:	MS 9715
SMILES:	O=C([C@H]1N(C([C@@H](NC(CCCCCCCCNC(CCCNCC2=CC(C)=C(C3=C(C4=CC=NC5=CC(F)=CC=C45)N(C)C=N3)C(C)=C2)=O)=O)C(C)(C)C)=O)C[C@H](O)C1)N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C
Formula:	C₅₈H₇₄FN₉O₅S
M.Wt:	1028.346
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	1. Chenxi Xu, et al. Cell Chem Biol. 2021 Aug 30;S2451-9456(21)00393-7.

Description:

MS9715 (MS-9715) is a NSD3-targeting PROTAC designed by linking BI-9321, a NSD3 antagonist, which binds NSD3's PWWP1 domain, with an E3 ligase VHL ligand.MS9715 achieves effective and specific targeting of NSD3 and associated cMyc node in tumor cells.MS9715 effectively suppresses growth of NSD3-dependent hematological cancer cells.MS 9715 effectively suppresses NSD3-and cMyc-associated gene expression programs, resembling effects of the CRISPR-Cas9-mediated knockout of NSD3.

References:

1. Chenxi Xu, et al. Cell Chem Biol. 2021 Aug 30;S2451-9456(21)00393-7.

MSDS

COA

LOT NO.	DOWNLOAD
2018-0101

Cat. No.	Product name	Field of application
DC70621	MS9715	MS9715 (MS-9715) is a NSD3-targeting PROTAC designed by linking BI-9321, a NSD3 antagonist, which binds NSD3's PWWP1 domain, with an E3 ligase VHL ligand.MS9715 achieves effective and specific targeting of NSD3 and associated cMyc node in tumor cells.MS9715 effectively suppresses growth of NSD3-dependent hematological cancer cells.MS 9715 effectively suppresses NSD3-and cMyc-associated gene expression programs, resembling effects of the CRISPR-Cas9-mediated knockout of NSD3.
DC70620	MS934	MS934 (MS-934) is a VHL-recruiting MEK1/2 degrader (PROTAC) with HT29 DC50 of 18/9 nM for MEK1/2 degradation, respectively.MS934 is more potent at inhibiting the growth of HT-29, SK-MEL-28, H3122, and SUDHL1 cells. MS934 also displays good plasma exposure in mice.