NCATS-SM5637 Datasheet DC Chemicals

Description	NCATS-SM5637 (NSC 791985) is a potent, selective mutant IDH1 inhibitor with IC50 of 81/72 nM for IDH1 mutant R132H/R132C, respctively.NCATS-SM5637 showed higher tumoral concentrations that corresponded to lower 2-HG concentrations in engineered mIDH1-U87-xenograft mouse model, compared with the approved drug AG-120 (ivosidenib).
Cat.No	DC70642
Name	NCATS-SM5637

Chemical Properties

CAS	2170615-16-2
Formula	C31H30CL2N4O2S
MW	593.567
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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