NCATS-SM5637|CAS 2170615-16-2|DC Chemicals

Cas No.:	2170615-16-2
Chemical Name:	NCATS-SM5637
Synonyms:	NSC 791985
Formula:	C₃₁H₃₀Cl₂N₄O₂S
M.Wt:	593.567
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

MSDS

COA

Cat. No.	Product name	Field of application
DC44726	Enasidenib Mesylate	Enasidenib (Idhifa, AG-221) mesylate is an orally available, selective and potent inhibitor of mutant isocitrate dehydrogenase 2 (IDH2).
DC28576	DS-1001b	DS-1001b is a mutant IDH-1 (Isocitrate Dehydrogenase-1) inhibitor extracted from patent WO2016052697A1, Example 168, and has antitumor activity.
DC72374	(S,S)-GSK321	(S,S)-GSK321 is a (S,S)-enantiomer of GSK321.
DC70642	NCATS-SM5637	NCATS-SM5637 (NSC 791985) is a potent, selective mutant IDH1 inhibitor with IC50 of 81/72 nM for IDH1 mutant R132H/R132C, respctively.NCATS-SM5637 showed higher tumoral concentrations that corresponded to lower 2-HG concentrations in engineered mIDH1-U87-xenograft mouse model, compared with the approved drug AG-120 (ivosidenib).
DC49742	AGI-12026	AGI-12026 is brain-penetrant dual inhibitor of mutant IDH1 and 2. AGI-12026 shows partial inhibition of the IDH1-R132H homodimer as allosteric modulators. AGI-12026 has the potential for research of glioma.
DC48219	Safusidenib	Safusidenib is a novel IDH1 inhibitor for the treatment of IDH1-mutated tumors.