DC Chemicals
-Chemicals for Life Science
-competitive price and high quality!www.dcchemicals.com
COA of PLX-3618
Description:
PLX-3618 is a targeted molecular glue that induces the degradation of BRD4, a key epigenetic regulator implicated in cancer. It achieves potent BRD4 degradation (DC50 = 12.2 nM) by recruiting the E3 ubiquitin ligase adapter DCAF11, which tags BRD4 with polyubiquitin chains for proteasome-mediated destruction.
Chemical Information
| Catalog | Featured products |
|---|---|
| Purity of current batch | >98% |
| CAS | 2851986-76-8 |
| Molecular Weight (MW) | 601.680883646011 |
| Molecular Formula | C32H27N9O2S |
| Storage | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Handling:
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.