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PLX-3618

  Cat. No.:  DC67339   Featured
Chemical Structure
2851986-76-8
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More than 5000 active chemicals with high quality for research!
Field of application
PLX-3618 is a targeted molecular glue that induces the degradation of BRD4, a key epigenetic regulator implicated in cancer. It achieves potent BRD4 degradation (DC50 = 12.2 nM) by recruiting the E3 ubiquitin ligase adapter DCAF11, which tags BRD4 with polyubiquitin chains for proteasome-mediated destruction.
Cas No.: 2851986-76-8
Chemical Name: PLX-3618
Synonyms: 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 2,3,9-trimethyl-4-[3′-[(pyrazolo[1,5-a]pyrimidin-3-ylcarbonyl)amino][1,1′-biphenyl]-4-yl]-, (6S)-
SMILES: CC1=C(SC2N3C(=NN=C3[C@@H](N=C(C3C=CC(C4C=CC=C(C=4)NC(C4C=NN5C=CC=NC=45)=O)=CC=3)C=21)CC(=O)N)C)C
Formula: C32H27N9O2S
M.Wt: 601.680883646011
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Cat. No. Product name Field of application
DC60948 NEK7 degrader (Compound 17) NEK7 degrader-1 is a NEK7 molecular glue degrader with a DC50 of 9  nM. NEK7 degrader-1 dose-dependently inhibits caspase-1 activity and IL-Ιβ release in macrophages in response to NLRP3 inflammasome activation. NEK7 degrader-1 can be used for autoinflammatory and autoimmune disorders like multiple sclerosis, neurodegeneraive diseases like Alzheimer's disease and cardiovascular and melabolic disorders like pericarditis and Type 2 diabetes research.
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DC68071 JHU-MDM2-P03
DC68070 CAS-FAK-P02
DC68069 MDA-S24-P01
DC68068 TB-008
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