AC-55649|cas 59662-49-6|DC Chemicals

Cas No.:	59662-49-6
Chemical Name:	[1,1'-Biphenyl]-4-carboxylicacid, 4'-octyl-
Synonyms:	[1,1'-Biphenyl]-4-carboxylicacid, 4'-octyl-;4-(4-octylphenyl)benzoic acid;4-Octyl-4'-biphenylcarboxylic acid;4-OCTYLBIPHENYL ACID;AC 55649;4-n-octylbiphenyl-4'-carboxylic acid;4'-octyl-4-phenylbenzoic acid;4'-Octylbiphenyl-4-carboxylic acid;4'-octyloxy-4-biphenylcarboxylic acid;8BCA;octyldiphenylcarboxylic acid;4′-Octyl-4-biphenylcarboxylic acid, 4′-n-octylbiphenyl-4-carboxylic acid;AC-55649
SMILES:	CCCCCCCCC1=CC=C(C=C1)C2=CC=C(C(O)=O)C=C2
Formula:	C₂₁H₂₆O₂
M.Wt:	310.42994
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	AC-55649 is a potent, highly isoform-selective agonist of human RARβ2 receptor, with a pEC50 of 6.9.
Target:	RARβ2:6.9 (pEC50)
In Vitro:	AC-55649 is a potent, highly isoform-selective agonist at the human RARβ2 receptor, with a pEC50 of 6.9[1]. AC-55649 is a potent and selective activator of RARβ2 transcriptional activity[2].
References:	[1]. Lund BW, et al. Discovery of a potent, orally available, and isoform-selective retinoic acid beta2 receptor agonist. J Med Chem. 2005 Dec 1;48(24):7517-9. [2]. Piu F, et al. Identification of novel subtype selective RAR agonists. Biochem Pharmacol. 2005 Dec 19;71(1-2):156-62.

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