8-Br-7-CH-cADPR disodium|CAS |DC Chemicals

Cas No.:
Chemical Name:	8-Br-7-CH-cADPR disodium
SMILES:	N=C1C(C=C(Br)N2[C@H]3[C@H](O)[C@H](O)[C@@H](COP4(O[Na])=O)O3)=C2N=CN1[C@H]5[C@H](O)[C@H](O)[C@@H](COP(O4)(O[Na])=O)O5
Formula:	C₁₆H₁₉BrN₄Na₂O₁₃P₂
M.Wt:	663.17
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
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DC70883	VK-II-86	VK-II-86 is a carvedilol analogue lacking antagonist activity at β-adrenoceptors, effectively suppresses SOICR by directly reducing the open duration of the cardiac ryanodine receptor (RyR2).VK-II-86 exhibited >2,000-fold lower beta-AR binding affinity than carvedilol.VK-II-86 prevented stress-induced ventricular tachyarrhythmias in RyR2-mutant mice and did so more effectively when combined with either of the selective beta blockers metoprolol or bisoprolol.VK-II-86 prevented hypokalaemia-induced AP prolongation and depolarization but did not alter AP parameters in normokalaemia.
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