AkaLumine|CAS 1176235-08-7|DC Chemicals

Cas No.:	1176235-08-7
Chemical Name:	2-[(1E,3E)-4-(4-Dimethylaminophenyl)buta-1,3-dienyl]-4,5-dihydrothiazole-4-carboxylic acid
Synonyms:	AkaLumine; Aka Lumine
SMILES:	O=C(C1N=C(/C=C/C=C/C2=CC=C(N(C)C)C=C2)SC1)O
Formula:	C₁₆H₁₈N₂O₂S
M.Wt:	302.39
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

AkaLumine is a luciferin analogue. The bioluminescence produced by AkaLumine in reactions with native firefly luciferase is in the near-infrared wavelength ranges (λmax=677?nm), and yields significantly increased target-detection sensitivity from deep tissues with maximal signals attained at very low concentrations, as compared with D-luciferin and emerging synthetic luciferin CycLuc1.

Cat. No.	Product name	Field of application
DC67528	Ac-AEVD-pN(Caspase-10 Substrate)	This product is a ready-to-use colorimetric substrate for Caspases that recognize the amino acid sequence AEVD. Caspase activity can be quantified by spectrophotometric detection of free pNA (l = 400 nm) after cleaved from the peptide substrate AEVD-pNA, using a spectrophotometer or multi-well plate reader.
DC67527	Ac-LEVD-pNA（caspase-4 substrate)	Ac-LEVD-pNA is a chromogenic substrate for caspase-4 and can be used to detect caspase-4 activity.
DC60824	Ac-LETD-AFC	Ac-LETD-AFC is a caspase-8 fluorogenic substrate. Ac-LETD-AFC can measure caspase-8 fluorogenic activity and can be used for the research of cancer cell apoptosis and oxidative stress metabolism.
DC60823	Ac-ATAD-AFC(Caspase-12 Substrate)	Ac-ATAD-AFC(Caspase-12 Substrate) is a fluorogenic substrate for caspase-12.
DC67320	S-2732 Suc-lle-Glu (y-Pip) -Gly-Arg-pNA hydrochloride	The activated factor X (FXa)-specific chromogenic substrate S-2732 is a short peptide covalently bound to pNA (4-nitroaniline). A free pNA will be cleaved off the peptide chain by activated factor X, thus enabling quantitive detection by a spectrophotometer.
DC67319	S-2403(chromogenic substrate for plasmin and streptokinase-activated plasminoge)	S-2403 is a chromogenic substrate for plasmin and streptokinase-activated plasminoge
DC67318	S2366 HCl（chromogenic substrate for Factor XI ）	S2366 HCl is a chromogenic substrate for Factor XI in plasma.
DC67293	D-Val-Gly-Arg-pNA	D-Val-Gly-Arg-p-nitroaniline (D-VGR-pNA) is a synthetic chromogenic peptide substrate specifically designed for assessing the enzymatic activity of tissue plasminogen activator (tPA), including its isoforms tPA I and tPA II. Upon cleavage by tPA, the release of p-nitroaniline (pNA) generates a measurable colorimetric signal, enabling precise quantification of amidolytic activity. This substrate is widely utilized in biochemical assays to study tPA’s role in fibrinolysis and to evaluate its enzymatic kinetics in both research and diagnostic applications.
DC67279	Rhobo6	Rhobo6 is a cell-impermeable small-molecule fluorophore designed for labeling the extracellular matrix (ECM) in live tissues. It contains a phenylboronic acid group that binds to diols commonly found in ECM glycans, resulting in a significant increase in fluorescence and a red shift in emission spectra. This property allows Rhobo6 to effectively visualize ECM architecture without perturbing native structures, making it suitable for long-term imaging studies. Additionally, Rhobo6's low affinity for monosaccharides enables reversible binding, which prevents photobleaching and allows for dynamic imaging of ECM components. While Rhobo6 does not specifically target individual ECM components, it provides a holistic view of ECM distribution and is particularly useful for studying ECM-related biological phenomena in samples that are not amenable to genetic manipulation or ex vivo culture.Rhobo6 is available under license from the Howard Hughes Medical Institute.
DC65436	AkaLumine hydrochloride	AkaLumine hydrochloride is a luciferin analogue, with a Km of 2.06 μM for recombinant Fluc protein.