CAY10444|CAS 298186-80-8|DC Chemicals

Cas No.:	298186-80-8
Chemical Name:	(4R)-2-Undecyl-4-thiazolidinecarboxylic acid
Synonyms:	CAY10444; CAY-10444; CAY 10444; BML-241; BML 241; BML241;
SMILES:	O=C([C@H]1NC(CCCCCCCCCCC)SC1)O
Formula:	C₁₅H₂₉NO₂S
M.Wt:	287.46
Purity:	>98%
Sotrage:	Please store the product under the recommended conditions in the Certificate of Analysis.
Publication:	[1]. Salvatore Salomone, et al. Selectivity and specificity of sphingosine-1-phosphate receptor ligands: caveats and critical thinking in characterizing receptor-mediated effects. Front Pharmacol. 2011 Feb 22;2:9.

Description:	CAY10444 (BML-241) is a sphingosine-1-phosphate 3 (S1P3) antagonist. CAY10444 inhibits by 37% S1P-induced increases in Ca2+ in HeLa cells expressing S1P3 receptors[1].
Target:	S1PR3
In Vitro:	BML-241 inhibits increases in intracellular Ca2+ concentration via P2 receptor or α1A-adrenoceptor stimulation and α1A-adrenoceptor-mediated contraction of rat mesenteric artery, while it does not affect S1P3-mediated decrease of Forskolin-induced cyclic AMP accumulation[1].
References:	[1]. Salvatore Salomone, et al. Selectivity and specificity of sphingosine-1-phosphate receptor ligands: caveats and critical thinking in characterizing receptor-mediated effects. Front Pharmacol. 2011 Feb 22;2:9.

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