CFI-400437|CFI400437|PLK4 inhibitor|DC Chemicals

Cas No.:	1247000-76-5
Chemical Name:	CFI-400437 HCl
Synonyms:	CFI 400437,CFI400437
SMILES:	CN1CCN(CC1)C2=NC=C(C=C2)/C=C/C3=NNC4=C3C=CC(=C4)/C=C/5\C6=C(C=CC(=C6)OC)NC5=O.Cl.Cl
Formula:	C₂₉H₃₀Cl₂N₆O₂
M.Wt:	565.5
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	CFI-400437 is potent against PLK4 (IC50 = 0.6 nM) and selective against other members of the PLK family (>10 uM).
In Vitro:	CFI-400437 is potent against PLK4 (IC50 = 0.6 nM) and selective against other members of the PLK family (>10 uM). Against a broad panel of kinases, only a small subset is significantly inhibited. CFI-400437 is a potent inhibitor of MCF-7, MDA-MB-468, and MDA-MB-231 cell growth and very effective in a mouse xenograft model of tumor growth

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