mutant EGFR inhibitor B30|cas 2225887-26-1|DC Chemicals

Cas No.:	2225887-26-1
Chemical Name:	(1-(6-((5-(4-(dimethylamino)piperidin-1-yl)pyridin-2-yl)amino)-2-((4-fluorophenyl)amino)pyrido[3,4-d]pyrimidin-4-yl)piperidin-4-yl)methanol
SMILES:	C(C1CCN(C2N=C(NC3=CC=C(F)C=C3)N=C3C=NC(NC4=NC=C(N5CCC(N(C)C)CC5)C=C4)=CC3=2)CC1)O
Formula:	C₃₁H₃₈FN₉O
M.Wt:	571.705
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	mutant EGFR inhibitor B30(EGFR-IN-5) is a EGFR inhibitor with IC50s of 10.4, 1.1, 34, 7.2 nM for EGFR, EGFRL858R, EGFRL858R/T790M, and EGFRL858R/T790M/C797S, respectively.
Target:	EGFR:10.4 nM (IC50) EGFRL858R:1.1 nM (IC50) EGFRL858R/T790M:34 nM (IC50) EGFRL858R/T790M/C797S:7.2 nM (IC50)
References:	[1]. Zhang H, et al. Discovery of 2,4,6-trisubstitued pyrido[3,4-d]pyrimidine derivatives as new EGFR-TKIs. Eur J Med Chem. 2018 Mar 25;148:221-237.

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