HDAC6 degrader 9c|dHDAC6 9c

Cas No.:	2235382-05-3
Chemical Name:	(E)-8-(2-(4-(2-(2-(2-(4-(((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)methyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)benzylidene)hydrazinyl)-N-hydroxy-8-oxooctanamide
Synonyms:	dHDAC6 9c
SMILES:	C(NO)(=O)CCCCCCC(N/N=C/C1=CC=C(OCCOCCOCCN2C=C(CNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)C=C1)=O
Formula:	C₃₇H₄₅N₉O₁₀
M.Wt:	775.82
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

HDAC6 degrader 9c (dHDAC6 9c) is a bifunctional molecule (dHDAC6) that could selectively degrade HDAC6, by conjugating non-selective HDAC inhibitor to a thalidomide-type E3 ligase ligand; causes degradation of HDAC6 in a dose dependent manner (DC50=34 nM), upregulate the level of acetylated α-tubulin at 1.1 uM; shows the maximal effect of HDAC6 degradation at 80 nM in the MM.1S cell line.

Cat. No.	Product name	Field of application
DC47585	PROTAC CDK9 ligand-1	PROTAC CDK9 ligand-1 is a CDK9 ligand that can be used in the synthesis of PROTACs.
DC47584	PROTAC BRD4 ligand-2	PROTAC BRD4 ligand-2 is a ligand for target BRD4 protein for PROTAC CFT-2718.
DC47372	Bromo-C10-OBn	Bromo-C10-OBn is a PROTAC linker that can be used in the synthesis of PROTACs.
DC47371	1-Bromo-6-chlorohexane	1-Bromo-6-chlorohexane is a PROTAC linker can be used in the synthesis of PROTACs.
DC47370	Biotinyl-NH-PEG3-C3-amido-C3-COOH (DIPEA)	Biotinyl-NH-PEG3-C3-amido-C3-COOH (DIPEA) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
DC47369	Propargyl-PEG2-CH2COOH	Propargyl-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
DC47319	Dovitinib-RIBOTAC	Dovitinib RIBOTAC is a targeted RNA degrader that cleaves pre-miR-21 with enhanced potency and selectivity.
DC47213	L-Homopropargylglycine hydrochloride	L-Homopropargylglycine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. L-homopropargylglycine hydrochloride is an amino acid analog of methionine containing an alkyne moiety that can undergo a classic click chemical reaction with azide containing Alexa Fluor.
DC47212	Boc-bipiperidine-ethynylbenzoic acid	Boc-bipiperidine-ethynylbenzoic acid is an Alkyl/ether-based PROTAC linker can be used in the synthesis of ARD-61.
DC47193	OICR-9429-N-C2-NH2	OICR-9429-N-C2-NH2 is a ligand for Wd40 repeat domain protein 5 (WDR5) extracted from patent WO2019246570A1, intermediate 2. OICR-9429-N-C2-NH2 can be used in the synthesis of PROTACs.