NOSO-502|NOSO502;NOSO 502

Cas No.:	1894081-09-4
Chemical Name:	(Z)-2-((S)-6-amino-2-((S)-2-((S)-1-((2R,8S,11S,14S)-14,18-diamino-11-((S)-2-amino-1-hydroxyethyl)-8-(2-aminoethyl)-2-(3-aminopropyl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazaoctadecanoyl)pyrrolidine-2-carboxamido)-3-(2-fluorophenyl)propanamido)hexanamido)-5-gu
Synonyms:	NOSO502;NOSO 502
SMILES:	C(O)(=O)/C(/NC(=O)[C@H](NC(=O)[C@H](NC([C@H]1CCCN1C(=O)[C@H](CCCN)NC(=O)CNC(=O)[C@@H](CCN)NC(=O)[C@@H]([C@H](O)CN)NC(=O)[C@H](N)CCCCN)=O)CC1=CC=CC=C1F)CCCCN)=C/CCNC(N)=N
Formula:	C₄₇H₈₀FN₁₇O₁₁
M.Wt:	1078.263
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

NOSO-502 (NOSO502) is a novel inhibitor of bacterial translation, has MIC values of 0.5-4 ug/ml against standard Enterobacteriaceae strains and carbapenem-resistant Enterobacteriaceae (CRE) isolates that produce KPC, AmpC, or OXA enzymes and metallo-β-lactamases; interacts strongly with a specific site on the 30S subunit of bacterial ribosomes but has no significant activity against any of the 55 cell surface receptors, transporters, or ion channels; NOSO-502 is active against a panel of Gram-positive and Gram-negative bacteria, including carbapenem-resistant and polymyxin-resistant strains, and exhibits promising in vivo activity in various murine infection models, a favorable in vitro safety profile, and a low potential for resistance development.

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