FTBMT|CAS 1358575-02-6|DC Chemicals

Cas No.:	1358575-02-6
Chemical Name:	4-(3-(3-Fluoro-5-(trifluoromethyl)benzyl)-5-methyl-1H-1,2,4-triazol-1-yl)-2-methylbenzamide
SMILES:	C(N)(=O)C1=CC=C(N2C(C)=NC(CC3=CC(C(F)(F)F)=CC(F)=C3)=N2)C=C1C
Formula:	C₁₉H₁₆F₄N₄O
M.Wt:	392.35
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	FTBMT is a selective GPR52 agonist with an EC50 of 75 nM[1]. Antipsychotic and procognitive properties[2].
Target:	IC50: 75 nM (GPR52)[1].
In Vivo:	FTBMT (30 mg/kg) exhibits antipsychotic-like activity without causing catalepsy in mice[2].
In Vitro:	FTBMT (0.1-10 μM) increases intracellular cAMP levels in CHO cells expressing human, mouse, or rat GPR52, with pEC50s of 7.03 6 0.04, 6.85 6 0.02, and 6.87 6 0.02[2].
References:	[1]. Tokumaru K, et al. Design, synthesis, and pharmacological evaluation of 4-azolyl-benzamide derivatives as novel GPR52 agonists. Bioorg Med Chem. 2017 Jun 15;25(12):3098-3115. [2]. Nishiyama K, et al. FTBMT, a Novel and Selective GPR52 Agonist, Demonstrates Antipsychotic-Like and Procognitive Effects in Rodents, Revealing a Potential Therapeutic Agent for Schizophrenia. J Pharmacol Exp Ther. 2017 Nov;363(2):253-264.

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