Qstatin|CAS 902688-24-8|quorum sensing (QS) inhibitor

Cas No.:	902688-24-8
Chemical Name:	1-(5-bromothiophene-2-sulfonyl)-1H-pyrazole
SMILES:	N(S(C1SC(Br)=CC=1)(=O)=O)1C=CC=N1
Formula:	C₇H₅BrN₂O₂S₂
M.Wt:	293.153
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

QStatin is a novel, potent, and selective Vibrio quorum sensing (QS) inhibitor, shows pan-QS inhibitor activity in diverse Vibrio species. QStatin attenuates representative QS-regulated phenotypes in various Vibrio speciesbinds tightly to a putative ligand-binding pocket in SmcR and changes the flexibility of the protein, thereby altering its transcription regulatory activity. QStatin may be a sustainable antivibriosis agent useful in aquacultures[1].

References:

[1]. Kim BS, et al. QStatin, a Selective Inhibitor of Quorum Sensing in Vibrio Species. MBio. 2018 Jan 30;9(1). pii: e02262-17.

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