| Cas No.: | 2158198-77-5 |
| Chemical Name: | (E)-3-(3-bromo-4-hydroxy-5-methoxyphenyl)-2-cyano-N-(2,4-dichlorophenyl)acrylamide |
| SMILES: | C(NC1=CC=C(Cl)C=C1Cl)(=O)/C(/C#N)=C/C1=CC(OC)=C(O)C(Br)=C1 |
| Formula: | C17H11BrCl2N2O3 |
| M.Wt: | 442.09 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | The first selective, cell-permeable inhibitor of GAG sulfotransferases with IC50 of 2.0-2.5 uM ; displays 8- to 18-fold greater specificity for GAG sulfotransferases compared to cytosolic sulfotransferases; decreases chondroitin sulfate-E (CS-E) and overall sulfation levels on cell-surface and secreted chondroitin sulfate proteoglycans (CSPGs), and reverses CSPG-mediated inhibition of axonal growth. |

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