ABD328|ABD-328;ABD 328

Cas No.:	1055896-19-9
Chemical Name:	1-(2',4'-dichloro-[1,1'-biphenyl]-4-yl)-6-hydroxyhexan-1-one
Synonyms:	ABD-328;ABD 328
SMILES:	C(C1=CC=C(C2=CC=C(Cl)C=C2Cl)C=C1)(=O)CCCCCO
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

ABD328 (ABD-328) is an orally active, small molecule inhibitor of RANKL and TNF signalling that inhibits inflammation in vivo; inhibits TNF-induced activation of the NF-κB pathway, ERK, JNK and MAPKs in osteoclasts and macrophages, suppresses inflammatory arthritis, inhibits joint destruction and prevented systemic bone loss in mice model of rheumatoid arthritis.

Cat. No.	Product name	Field of application
DC47551	IMD-vanillin	IMD-vanillin is a novel imidazoquinolinone-NF-κB immunomodulator dimers.
DC47550	HE 3286	HE3286, a synthetic derivative of the adrenal steroid β-AET, is an orally-active partially NF-κB inhibitor.
DC47549	IMD-biphenylA	IMD-biphenylA is a novel imidazoquinolinone-NF-κB immunomodulator dimer that improves the adjuvanticity of small molecule immune potentiators.
DC47548	IMD-ferulic	IMD-ferulic is a covalently linked NF-κB modulator that improves the adjuvanticity of small molecule immune potentiators.
DC47547	Lucyoside B	Lucyoside B inhibits the production of inflammatory mediators via both NF-κB and activator protein-1 pathways in activated macrophages.
DC47546	Rubioncolin C	Rubioncolin C exerts anti-tumor activity by inducing apoptotic and autophagic Cell Death and inhibiting the NF-κB and Akt/mTOR/P70S6K Pathway in Human Cancer Cells.
DC47545	IMD-biphenylC	IMD-biphenylC is a novel imidazoquinolinone-NF-κB immunomodulator dimer that inhibits tumor proliferation while induces low systemic inflammation and reduces adjuvant toxicity.
DC47544	IMD-catechol	IMD-catechol is a novel imidazoquinolinone-NF-κB immunomodulator dimer that improves efficacy in a CT26 mouse colon carcinoma tumor model while eliciting minimal adjuvant toxicity.
DC46510	Sulfuretin	Sulfuretin inhibits the inflammatory response by suppressing the NF-κB pathway. Sulfuretin can be used for the research of allergic airway inflammation. Sulfuretin reduces oxidative stress, platelet aggregation, and mutagenesis. Sulfuretin is a competitive and potent inhibitor of monophenolase and diphenolase activities with the IC50 of 13.64 μM.
DC46210	PTD-p65-P1 Peptide	PTD-p65-P1 Peptide is a nuclear transcription factor NF-kappaB inhibitor, composed of a membrane-translocating peptide sequence generated from antennapedia (PTD) conjugated with p65-P1, which selectively inhibits activation induced by various inflammatory stimuli.