PF-06737007|cas 1863905-38-7|DC Chemicals

Cas No.:	1863905-38-7
Chemical Name:	Chembl4203759
Synonyms:	2-((3R,4S)-3-Fluoro-1-(2-(4-(trifluoromethoxy)phenyl)acetyl)piperidin-4-yloxy)-4-(2-hydroxy-2-methylpropoxy)benzamide;2-{[(3R,4S)-3-fluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl]oxy}-4-(2-hydroxy-2-methylpropoxy)benzamide;TQR0432;BDBM50457827;2-(((3R,4S)-3-fluoro-1-(2-(4-(trifluoromethoxy)phenyl)acetyl)piperidin-4-yl)oxy)-4-(2-hydroxy-2-methylpropoxy)benzamide;GO7;Chembl4203759
SMILES:	F[C@]1([H])C([H])([H])N(C(C([H])([H])C2C([H])=C([H])C(=C([H])C=2[H])OC(F)(F)F)=O)C([H])([H])C([H])([H])[C@@]1([H])OC1C([H])=C(C([H])=C([H])C=1C(N([H])[H])=O)OC([H])([H])C(C([H])([H])[H])(C([H])([H])[H])O[H]
Formula:	C₂₅H₂₈F₄N₂O₆
M.Wt:	528.4932
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	PF-06737007 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 7.7 nM, 15 nM and 3.9 nM for TrkA, TrkB and TrkC, respectively[1]. Anti-hyperalgesic effect[1].
Target:	TrkA:7.7 nM (IC50, in cell-based assays) TrkB:15 nM (IC50, in cell-based assays) TrkC:3.9 nM (IC50, in cell-based assays)
In Vitro:	PF-06737007 (Compound 13b) exhibits superb Trk selectivity with >95% inhibition of TrkA with no other kinase being inhibited by >40% at 1 μM[1].
References:	[1]. Bagal SK, et al. Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain. J Med Chem. 2018 Aug 9;61(15):6779-6800.

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