TP0427736 |CAS TP0427736|DC Chemicals

Cas No.:	864374-00-5
Chemical Name:	BENZOTHIAZOLE, 6-[5-(4-METHYL-2-THIAZOLYL)-1H-IMIDAZOL-4-YL]-
Synonyms:	BENZOTHIAZOLE, 6-[5-(4-METHYL-2-THIAZOLYL)-1H-IMIDAZOL-4-YL]-;TP0427736;TP0427736 HCl;TP427736;TP-427736;6-[4-(4-methyl-1,3-thiazol-2-yl)-1h-imidazol-5-yl]-1,3-benzothiazole;6-[4-(4-methyl-1,3-thiazol-2-yl)-1h-imidazol-5-yl]-1,3-benzothiazole;6-[4-(4-methyl-1,3-thiazol-2-yl)-1h-imidazol-5-yl]-1,3-benzothiazole;AC-31418;AC-31418;AC-31418;CHEMBL2207988;CHEMBL2207988;CHEMBL2207988;6-[5-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-4-yl]-1,3-benzothiazole;6-[5-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-4-yl]-1,3-benzothiazole;6-[5-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-4-yl]-1,3-benzothiazole;6-(4-(4-Methylthiazol-2-yl)-1H-imidazol-5-yl)benzo[d]thiazole;6-(4-(4-Methylthiazol-2-yl)-1H-imidazol-5-yl)benzo[d]thiazole;6-(4-(4-Methylthiazol-2-yl)-1H-imidazol-5-yl)benzo[d]thiazole;BDBM50402166;BDBM50402166;BDBM50402166;SCHEMBL13217824;SCHEMBL13217824;SCHEMBL13217824;HY-118528;HY-118528;HY-118528;TS-08405;TS-08405;TS-08405;EX-A6695;EX-A6695;6-[4-(4-Methyl-2-thiazolyl)-1H-imidazole-5-yl]benzothiazole;EX-A6695;864374-00-5;6-[4-(4-Methyl-2-thiazolyl)-1H-imidazole-5-yl]benzothiazole;6-[4-(4-Methyl-2-thiazolyl)-1H-imidazole-5-yl]benzothiazole;CS-0066275;864374-00-5;864374-00-5;AKOS040746422;CS-0066275;CS-0066275;AKOS040746422;AKOS040746422
SMILES:	CC1=CSC(=N1)C2=C(N=CN2)C3=CC4=C(C=C3)N=CS4
Formula:	C₁₄H₁₀N₄S₂
M.Wt:	298.386
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

In vitro TP0427736 inhibits Smad2/3 phosphorylation in a concentration-dependent manner, with an IC50 value of 8.68 nM. In a cell-based assay of outer root sheath cells, TP0427736 rescued the inhibited proliferation by TGF-β1 and TGF-β2 in a concentration-dependent manner. In vivo TP0427736 decreases shortening of hair follicle length during the transition from the late anagen phase to the catagen phase.

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