Barbadin||CAS 356568-70-2|DC Chemicals

Cas No.:	356568-70-2
Chemical Name:	Barbadin
Synonyms:	3-Azanyl-5-[4-(phenylmethyl)phenyl]thieno[2,3-d]pyrimidin-4-one
Formula:	C₁₉H₁₅N₃Os
M.Wt:	333.409
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Barbadin is a small molecule that selectively inhibits the β-arrestin/β2-adaptin interaction (IC50=19.1/15.6 uM for β-arrestin1/2) without effect on the formation of receptor/β-arrestin complexes; selectively inhibits the β-arrestin/AP2 interaction, blocks agonist-promoted endocytosis of the prototypical GPCR β2AR, V2R and AT1R, but does not affect β-arrestin-independent (transferrin) or AP2-independent (endothelin-A) receptor internalization, fully blocks V2R-stimulated ERK1/2 activation and blunts cAMP accumulation promoted by both V2R and β2AR.

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