CD38 inhibitor 78c|CAS 1700637-55-3|DC Chemicals

Cas No.:	1700637-55-3
Chemical Name:	MDK-7553
SMILES:	CN1C2=C(C=C(C=C2)C3=CN=CS3)C(=CC1=O)NC4CCC(CC4)OCCOC
Formula:	C₂₂H₂₇N₃O₃S
M.Wt:	413.536
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	CD38 inhibitor 78c is a potent CD38 inhibitor with IC50s of 7.3 nM and 1.9 nM for human and mouse, respectively[1].
In Vivo:	CD38 inhibitor (30 mg/kg; oral administration; 2 and 6 hours) significantly elevates NAD levels in liver and muscle[1]. Animal Model: Diet induced obese (DIO) C57Bl6 mice[1] Dosage: 30 mg/kg Administration: Orally once Result: NAD levels were significantly increased at both the 2 and 6 h time points in liver and muscle.

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