Golgicide A|cas 1139889-93-2|DC Chemicals

Cas No.:	1139889-93-2
Chemical Name:	Golgicide A
Synonyms:	Golgicide A
SMILES:	FC1C=C(F)C2=C([C@H]3C=CC[C@H]3C(C3C=CC=NC=3)N2)C=1
Formula:	C₁₇H₁₄F₂N₂
M.Wt:	284.303270816803
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Golgicide A is a potent, highly specific, and reversible inhibitor of the cis-Golgi ADP-ribosylation factor guanine nucleotide exchange factors (ArfGEF), GBF1[1].
Target:	GBF1[1]
In Vitro:	Golgicide A (GCA) is a potent and highly effective inhibitor of shiga toxin activity. Golgicide A (GCA) inhibits the effect of shiga toxin on protein synthesis with an IC50 of 3.3 μM[1].
References:	[1]. Sáenz JB, et al. Golgicide A reveals essential roles for GBF1 in Golgi assembly and function. Nat Chem Biol. 2009 Mar;5(3):157-65.

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