TRIF agonist AV-C|CAS 620589-62-0|DC Chemicals

Cas No.:	620589-62-0
Chemical Name:	1-(2-fluorophenyl)-2-(5-isopropyl-1,3,4-thiadiazol-2-yl)-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione
SMILES:	CC(C)C1=NN=C(S1)N2C(C3=C(C2=O)OC4=CC=CC=C4C3=O)C5=CC=CC=C5F
Formula:	C₂₂H₁₆FN₃O₃S
M.Wt:	421.446
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	TRIF agonist AV-C is a novel TRIF pathway agonist that activates innate and interferon-associated responses, strongly inhibits replication of ZIKV, CHIKV, and DENV (IC90~5 uM); activates IFNAR-mediated transcription and translation of antiviral effector genes, AV-C-mediated, IRF3-dependent innate activation occurs independently of adaptor proteins IPS-1/MAVS and STING but requires TRIF.
References:	References 1. Pryke KM, et al. MBio. 2017 May 2;8(3). pii: e00452-17. View Related Products by Target Other Targets

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