AT-130|cas 211364-06-6|DC Chemicals

Cas No.:	211364-06-6
Chemical Name:	Benzamide,N-[(1E)-2-bromo-2-(2-methoxyphenyl)-1-(1-piperidinylcarbonyl)ethenyl]-4-nitro-
SMILES:	COC1=C(C=CC=C1)C(/Br)=C(/NC(=O)C2=CC=C([N+](=O)[O-])C=C2)C(=O)N3CCCCC3
Formula:	C₂₂H₂₂N₃O₅Br
M.Wt:	488.33118
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

AT-130 is a potent inhibitor of HBV capsid assembly, inhibits wild-type HBV replication with IC50 of 2.4 uM; inhibits replication of wild-type and lamivudine-resistant strains of hepatitis B virus in vitro with same sensitivity (rtL180M, rtM204I, and rtL180M + rtM204V); blocks HBV replication at the level of viral RNA packaging, interferes with capsid morphogenesis, shows activity against the main lamivudine- and adefovir-resistant mutants.

References:

References 1. Delaney WE 4th, et al. Antimicrob Agents Chemother. 2002 Sep;46(9):3057-60. 2. Feld JJ, et al. Antiviral Res. 2007 Nov;76(2):168-77. 3. Billioud G, et al. Antiviral Res. 2011 Nov;92(2):271-6. View Related Products by Target HBV

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