ML298|CID53393915|CAS 1426916-02-0|DC Chemicals

Cas No.:	1426916-02-0
Chemical Name:	3,4-difluoro-N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-benzamide
SMILES:	FC1C=C(C=CC=1F)C(NCCN1CCC2(N(C3C=CC=C(F)C=3)CNC2=O)CC1)=O
Formula:	C₂₂H₂₃F₃N₄O₂
M.Wt:	432.438835382462
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	ML298 is a potent, selective phospholipase PLD2 inhibitor with IC50 of 355 nM, displays >53-fold selectivity over PLD1 (IC50>20 uM); decreases invasive migration in U87-MG glioblastoma cells; has an attractive DMPK profile, making it an attractive tool compound to further dissect PLD2 function in multiple cellular and in vivo environments.
References:	References 1. O'Reilly MC, et al. J Med Chem. 2013 Mar 28;56(6):2695-9. 2. Scott SA, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. View Related Products by Target Phospholipase

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