ML401 (CID73169083)|CAS 1597489-14-9

Cas No.:	1597489-14-9
Chemical Name:	(E)-3-(4-bromophenyl)-1-(4-(4-chlorobenzyl)-piperazin-1-yl)prop-2-en-1-one
Synonyms:	CID73169083; ML-401;ML 401;CID 73169083;CID-73169083
SMILES:	C1CN(CCN1CC2=CC=C(C=C2)Cl)C(=O)/C=C/C3=CC=C(C=C3)Br
Formula:	C₂₀H₂₀BrClN₂O
M.Wt:	419.747
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	ML401, a potent chemical probe, selectively antagonizes EBI2 (also known as GPR183) with an IC50 of 1.03 nM. ML401 displays activity in a chemotaxis assay (IC50=6.24 nM). ML401 shows good stability and no toxicity[1].
In Vivo:	ML401 shows very good stability in both human plasma and mouse plasma[1].
In Vitro:	ML401 shows no toxicity (>50 μM) towards immortalized Fa2-N4 human hepatocytes and non-cytotoxic in MTT in both LnCap and IMR-32 cells (>50 μM)[1].

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