CK 666|cas 442633-00-3|DC Chemicals

Cas No.:	442633-00-3
Chemical Name:	CK 666
Synonyms:	CK 666;2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide;2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-benzamide;CK-0944666
SMILES:	O=C(C1=CC=CC=C1F)NCCC1=C(C)NC2=CC=CC=C12
Formula:	C₁₈H₁₇FN₂O
M.Wt:	296.338787794113
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	CK-666 is a cell-permeable inhibitor of actin-related protein Arp2/3 complex, and binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocking movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation[1].
Target:	Arp2/3 complex[1]
References:	[1]. Hetrick B, et al. Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change. Chem Biol. 2013 May 23;20(5):701-12.

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