ENMD-1068|cas 789488-77-3|DC Chemicals

Cas No.:	789488-77-3
Synonyms:	6-amino-1-[4-(3-methylbutanoyl)piperazin-1-yl]hexan-1-one;6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone hydrochloride
SMILES:	NCCCCCC(N1CCN(C(=O)CC(C)C)CC1)=O
Formula:	C₁₅H₂₉N₃O₂
M.Wt:	283.409663915634
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

ENMD-1068 is a novel selective PAR2 antagonist without inhibitory activity against thrombin-mediated PAR3 and PAR4 signaling; blocks TNFα production in synovial explants from patients with arthritis, and inhibits mast cell tryptase-induced recruitment of eosinophils into the pleural cavity of mice, dose dependently attenuates joint inflammation.

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