GGTI 2417|CAS 501010-05-5|DC Chemicals

Cas No.:	501010-05-5
Chemical Name:	methyl (2S)-2-{(2S)-2-benzyl-4-(4-methyl-1H-imidazol-5-yl)methyl-3-oxopiperazine-1-carbonylamino}-4-methylpentanoate
Synonyms:	L-Leucine,N-[[(2S)-4-[(5-methyl-1H-imidazol-4-yl)methyl]-3-oxo-2-(phenylmethyl)-1-piperazinyl]carbonyl]-, methyl ester;GGTI-2417;DWKYALWDWAYMTB-FPOVZHCZSA-N;Reaxys ID: 11071519;GGTI 2417 (GGTI2417);L-Leucine, N-[[(2S)-4-[(4-methyl-1H-imidazol-5-yl)methyl]-3-oxo-2-(phenylmethyl)-1-piperazinyl]carbonyl]-, methyl ester;methyl (2S)-2-{(2S)-2-benzyl-4-(4-methyl-1H-imidazol-5-yl)methyl-3-oxopiperazine-1-carbonylamino}-4-methylpentanoate
SMILES:	C(OC)(=O)[C@H](CC(C)C)NC(N1CCN(CC2NC=NC=2C)C(=O)[C@@H]1CC1=CC=CC=C1)=O
Formula:	C₂₄H₃₃N₅O₄
M.Wt:	455.54992556572
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

GGTI 2417 is the methyl ester prodrug of GGTI-2418, a highly potent, competitive, and selective inhibitor of GGTase I; exhibits potent inhibitory activity against Rap1 geranylgeranylation with IC50 of 400 nM; increases p27 protein levels and induces accumulation in the G0/G1 phase as well as apoptotic cell death in breast cancer cells, and prevents the degradation of nuclear p27.

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