NNC 05-2090 hydrochloride |CAS 184845-18-9|DC Chemicals

Cas No.:	184845-18-9
Chemical Name:	NNC 05-2090 hydrochloride
Synonyms:	NNC 05-2090 hydrochloride;NNC05-2090 hydrochloride
SMILES:	Cl.COC1=CC=CC=C1C1(CCN(CCCN2C3=CC=CC=C3C3C=CC=CC2=3)CC1)O
Formula:	C₂₇H₃₁ClN₂O₂
M.Wt:	451.000246286392
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

NNC 05-2090 is a potent selective GABA transporter inhibitor of mGAT2 with Ki of 1.4 uM; displays >10 fold selectivity over mGAT1, mGAT3 and mGAT4, also has alpha 1- and D2-receptor affinity of 266 and 1632 nM, respectively; inhibits 3HGABA uptake into synaptosomes from cerebral cortex with IC50 of 4.4 uM; significantly reduces generalized seizure severity and afterdischarge duration in rats.

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