NSC 370284|cas 116409-29-1|DC Chemicals

Cas No.:	116409-29-1
Chemical Name:	1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]-
Synonyms:	NSC 370284;NSC-370284;NSC370284
SMILES:	COC1C(OC)=C(OC)C=C(C=1)C(N2CCCC2)C3C(O)=CC4=C(OCO4)C=3
Formula:	C₂₁H₂₅NO₆
M.Wt:	387.4263
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

NSC 370284 is a small molecule that directly binds to and inhibits STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo; shows no inhibitory effect on the viability of TET1-low AML (i.e., NB4) cells, function as TET1-transcription inhibitor in TET1-high AMLs and the anti-leukemic effects are TET1-dependent.

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