P11|PAFAH inhibitor P11

Cas No.:	942285-55-4
Chemical Name:	P11
Synonyms:	KUBDPRSHRVANQQ-NSOVKSMOSA-N;(2S,6S)-6-(4-tert-butylphenyl)-2-(4-methylphenyl)-1-(4-methylphenyl)sulfonyl-3,6-dihydro-2H-pyridine-5-carboxylic acid;PAFAH inhibitor P11;3 IN P11;3INP11;3-IN-P11;P11
SMILES:	[C@H]1(C2=CC=C(C(C)(C)C)C=C2)N(S(C2=CC=C(C)C=C2)(=O)=O)[C@@H](C2=CC=C(C)C=C2)CC=C1C(O)=O
Formula:	C₃₀H₃₃NO₄S
M.Wt:	503.652327299118
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

PAFAH inhibitor P11 (P11) is a potent, selective platelet-activating factor acetylhydrolases PAFAH1b2 and PAFAH1b3 inhibitor with IC50 of 40 nM and 900 nM respectively; blocks PAFAH1b2- and PAFAH1b3-mediated hydrolysis of the substrate PAF to lyso-PAF with IC50 values of 36 nM and 880 nM; impairs tumor cell survival; in situ-active and can be used to investigate the cellular functions of PAFAH1b2/3.

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