PF-05381941 |CAS 1474022-02-0|DC Chemicals

Cas No.:	1474022-02-0
Chemical Name:	PF-05381941
Synonyms:	PF-05381941
SMILES:	C1=C(C=CC(OC2C=CN=CC=2)=C1C)NC(=O)NC1=CC(=NN1C1C=CC=C(C#N)C=1)C(C)(C)C
Formula:	C₂₇H₂₆N₆O₂
M.Wt:	466.534345149994
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

PF-05381941 (PF 05381941, PF05381941) is a potent, dual TAK1/p38a inhibitor with IC50 of 156/186 nM respectively, with good kinome selectivity against 50 representative kinases; inhibits LPS-stimulated release of TNF-α from human peripheral mononuclear cells with IC50 of 8 nM.

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