PF-04802367|CAS 1962178-27-3|DC Chemiclas

Cas No.:	1962178-27-3
Chemical Name:	PF-04802367
Synonyms:	5-(3-Chloranyl-4-Methoxy-Phenyl)-~{n}-[3-(1,2,4-Triazol-1-Yl)propyl]-1,3-Oxazole-4-Carboxamide;N-(3-(1h-1,2,4-triazol-1-yl)propyl)-5-(3-chloro-4-methoxyphenyl)oxazole-4-carboxamide;Q27456523;6QH;PF-04802367
SMILES:	ClC1=C(C=CC(=C1)C1=C(C(NCCCN2C=NC=N2)=O)N=CO1)OC
Formula:	C₁₆H₁₆ClN₅O₃
M.Wt:	361.782941818237
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	. Liang SH, et al. Angew Chem Int Ed Engl. 2016 Aug 8;55(33):9601-5. View Related Products by Target GSK-3

Description:

A potent, highly selective GSK-3 inhibitor with IC50 of 2.1 nM for human GSK-3β in enzyme assays; shows equal effectivity against GSK-3α and GSK-3β with IC50 of 10.0 and 9.0 nM respectively in mobility shift assays, inhibits phosphorylation of tau with an IC50 of 466 nM in a stable inducible CHO cell line over-expressing GSK-3β and substrate tau; modulates tau phosphorylation in vitro and in vivo.

References:

. Liang SH, et al. Angew Chem Int Ed Engl. 2016 Aug 8;55(33):9601-5. View Related Products by Target GSK-3

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