PNU-112455A||CAS 21886-12-4|DC Chemicals

Cas No.:	21886-12-4
Chemical Name:	PNU112455A
Synonyms:	PNU112455A
SMILES:	NC1N=CN=C(NC2=CC=C(S(=O)(N)=O)C=C2)C=1
Formula:	C₁₀H₁₂ClN₅O₂S
M.Wt:	301.749
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	[1]. Clare PM, et al. The cyclin-dependent kinases cdk2 and cdk5 act by a random, anticooperative kinetic mechanism. J Biol Chem. 2001 Dec 21;276(51):48292-9.

Description:	PNU112455A hydrochloride is an ATP-competitive CDK2 and CDK5 inhibitor. PNU112455A hydrochloride binds to the ATP site of CDK2 and CDK5 with Kms of 3.6 and 3.2 μM, respectively [1].
Target:	CDK2:3.6 μM (Km) CDK5:3.2 μM (Km)
References:	[1]. Clare PM, et al. The cyclin-dependent kinases cdk2 and cdk5 act by a random, anticooperative kinetic mechanism. J Biol Chem. 2001 Dec 21;276(51):48292-9.

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