PRD125|PRD 125;PRD-125

Cas No.:	1642575-41-4
Chemical Name:	PRD125
SMILES:	O([C@@H]1[C@@]2(C)OC3=C([C@@H]([C@@]2([C@]2(C)[C@@]([H])(C1)[C@@]1(COC(O[C@]1(CC2)[H])C1C=CC=CC=1C)C)[H])O)C(=O)OC(=C3)C1C=CC=NC=1)C(C1C=CC(C#N)=CC=1)=O
Formula:	C₄₁H₄₀N₂O₈
M.Wt:	688.764911651611
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A potent and selective inhibitor of sterol O-acyltransferase 2 (SOAT2, ACAT2) with IC50 of 11.8 nM, >6,000-fold selectivity over ACAT1; markedly reduces hepatic cholesteryl ester accumulation and improves liver function in lysosomal acid lipase-deficient mice; improves both atherosclerosis and fatty liver progression in cholesterol diet-fed rabbits, shows more potent in vivo efficacy than atorvastatin.

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