CMP-5|PRMT5-IN-5

Cas No.:	880813-42-3
Chemical Name:	CMP-5
Synonyms:	cmp-5;1-(9-ethyl-9H-carbazol-3-yl)-N-(pyridin-2-ylmethyl)methanamine;STK723740;J3.626.951K;N-[(9-ethyl-9H-carbazol-3-yl)methyl]-N-(2-pyridinylmethyl)amine;9-Ethyl-N-(2-pyridinylmethyl)-9H-carbazole-3-methanamine (ACI);(9-Ethyl-9H-carbazol-3-ylmethyl)-pyridin-2-ylmethyl-amine;1-(9-Ethylcarbazol-3-yl)-N-(pyridin-2-ylmethyl)methanamine;CMP 5;DA-62424;CHEMBL4245087;CS-0076983;AN-465/43013180;880813-42-3;G13403;MS-24638;AKOS001479455;HY-120137;EX-A7640;SCHEMBL21308321
SMILES:	N1C(CNCC2C=C3C4C(N(C3=CC=2)CC)=CC=CC=4)=CC=CC=1
Formula:	C₂₁H₂₁N₃
M.Wt:	315.411544561386
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

CMP-5 (PRMT5-IN-5)is a first-in-class, small-molecule PRMT5-specific inhibitor that blocks EBV-driven B-lymphocyte transformation and survival, without effect on normal B cells; displays no activity against other type I (PRMT1 and PRMT4) and type II (PRMT7) enzymes; inhibition of PRMT5 leads to lost recruitment of a PRMT5/p65/HDAC3-repressive complex on the miR96 promoter, restored miR96 expression, and PRMT5 downregulation.

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