RO 5263397|RO5263397;RO-5263397

Cas No.:	1357266-05-7
Chemical Name:	RO5263397
Synonyms:	RO 5263397;(S)-4-(3-Fluoro-2-methylphenyl)-4,5-dihydrooxazol-2-amine;RO5263397;BDBM50158471
SMILES:	FC1=CC=CC(=C1C)[C@H]1COC(N)=N1
Formula:	C₁₀H₁₁FN₂O
M.Wt:	194.205545663834
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A highly potent, selective and orally bioavailable trace amine-associated receptor 1 (TRRA1) partial agonist with EC50 of 17 nM, >1,000-fold selectivity over human adrenergic α2A receptor; shows EC50 of 35 nM for rat TRRA1; blocks psychostimulant-induced hyperactivity and produces a brain activation pattern reminiscent of the antipsychotic drug olanzapine in vivo, does not induce catalepsy or weight gain, promotes vigilance in rats and shows pro-cognitive and antidepressant-like properties in rodent and primate models.

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