SMIFH2|cas 340316-62-3|DC Chemicals

Cas No.:	340316-62-3
Chemical Name:	(5e)-1-(3-bromophenyl)-5-(2-furylmethylene)-2-thioxodihydro-4,6(1 H,5h)-pyrimidinedione
Synonyms:	(5E)-1-(3-Bromophenyl)-5-(2-furylmethylene)-2-thioxodihydro-4,6(1 H,5H)-pyrimidinedione;SMIFH2;1-(3-Bromophenyl)-5-(2-furanylmethylene)dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione
SMILES:	BrC1=CC=CC(N2C(=O)/C(=C\C3=CC=CO3)/C(=O)NC2=S)=C1
Formula:	C₁₅H₉BrN₂O₃S
M.Wt:	377.212561368942
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

SMIFH2 is a small molecule formin homology 2 domains inhibitor of formin-mediated actin assembly, targets formins from evolutionarily diverse organisms including yeast, nematode worm, and mice with IC50s of 5-15 uM; prevents both formin nucleation and processive barbed end elongation and decreases formin's affinity for the barbed end; disrupts formin-dependent, but not Arp2/3 complex-dependent, actin cytoskeletal structures in fission yeast and mammalian NIH 3T3 fibroblasts at low micromolar concentrations.

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