SNAP-94847 hydrochloride|CAS 487051-12-7

Cas No.:	487051-12-7
Chemical Name:	N-(3-{1-[4-(3,4-Difluorophenoxy)benzyl]-4-piperidinyl}-4-methylphenyl)-2-methylpropanamide hydrochloride
Synonyms:	SNAP94847 hydrochloride SNA P94847 SNAP 94847
SMILES:	Cl.FC1=C(F)C=CC(OC2C=CC(CN3CCC(C4=C(C)C=CC(NC(=O)C(C)C)=C4)CC3)=CC=2)=C1
Formula:	C₂₉H₃₂F₂N₂O₂^.HCl
M.Wt:	515.042
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

SNAP 94847 is a novel, high affinity selective melanin-concentrating hormonereceptor1 (MCH1) antagonist with antidepressant-like activity, it differentiates from classic anxiolytic and antidepressant drugs.SNAP 94847 binds with high affinity to the mouse and rat MCHR1 with minimal cross-reactivity to other GPCR, ion channels, enzymes, and transporters.SNAP 94847 is a high affinity antagonist (pA2 = 7.81) of MCH-evoked inositol phosphate formation[1].

References:

[1]. David DJ, et al. Efficacy of the MCHR1 antagonist N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocampal neurogenesis. J Pharmacol Exp Ther. 2007 Apr;321(1):237-48. Epub 2007 Jan 19.

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