SR31527 |CAS 311814-78-5|DC Chemicals

Cas No.:	311814-78-5
Chemical Name:	SR31527
Synonyms:	SR31527;5-Amino-3-(4-methoxyphenyl)-2-phenyl-1,2,4-tiadiazolium chloride;3-(4-methoxyphenyl)-2-phenyl-1,2,4-thiadiazol-2-ium-5-amine;chloride;5-Amino-3-(4-methoxyphenyl)-2-phenyl-1,2,4-thiadiazol-2-ium chloride
SMILES:	[Cl-].S1C(N)=NC(C2C=CC(=CC=2)OC)=[N+]1C1C=CC=CC=1
Formula:	C₁₅H₁₄ClN₃Os
M.Wt:	319.809160709381
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

SR31527 is a novel allosteric Kinesin-like protein KIFC1 inhibitor that inhibits microtubule-stimulated KIFC1 ATPase activity with IC50 of 6.6 uM, binds directly to KIFC1 with Kd of 25.4 nM; prevents bipolar clustering of extra centrosomes in TNBC cells and significantly reducesTNBC cell colony formation and viability (MDA-MB-231, BT549 and MDA-MB-435s cells IC50=20-30 uM), with less toxicity to normal fibroblasts.

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