Gliocidin|DC Chemicals

Cas No.:	62289-81-0
Chemical Name:	N-(pyridin-3-yl)thiophene-2-carboxamide
Synonyms:	SW106065;MPNST-IN-21
SMILES:	O=C(NC1C=NC=CC=1)C2SC=CC=2
Formula:	C₁₀H₈N₂Os
M.Wt:	204.247
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	Nature-20 November 2024 Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma

Description:

Gliocidin is a prodrug that is anabolized into its tumoricidal metabolite, gliocidin–adenine dinucleotide (GAD). Gliocidin kills glioblastoma cells while sparing non-tumour replicative cells. Gliocidin activity targets a de novo purine synthesis vulnerability in glioblastoma through indirect inhibition of inosine monophosphate dehydrogenase 2 (IMPDH2). Gliocidin penetrates the blood–brain barrier and extends the survival of mice with orthotopic glioblastoma.

References:

Nature-20 November 2024 Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma

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