IP6K1 inhibitor TNP|cas 519178-28-0|DC Chemicals

Cas No.:	519178-28-0
Chemical Name:	Inositol-1,4,5-trisphosphate 3-Kinase Inhibitor
Synonyms:	Inositol-1,4,5-trisphosphate 3-Kinase Inhibitor;N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine;6-N-[(4-nitrophenyl)methyl]-2-N-[[3-(trifluoromethyl)phenyl]methyl]-7H-purine-2,6-diamine;TNP;N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine; N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-9H-Purine-2,6-diamine; N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-1H-Purine-2,6-diamine
SMILES:	O=[N+](C1C=CC(CNC2=NC(NCC3C=CC=C(C(F)(F)F)C=3)=NC3N=CNC2=3)=CC=1)[O-]
Formula:	C₂₀H₁₆F₃N₇O₂
M.Wt:	443.381953239441
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

IP6K1 inhibitor TNP is a potent, selective inositol hexakisphosphate kinase IP6K with IC50 of 0.47 uM (IP6K1), does not inhibit either human or yeast Vip/PPIP5K; reversibly inhibits InsP7 and InsP8 synthesis in vivo without affecting levels of other inositol phosphates; increases the IGF-1 elicited stimulation of T308 phosphorylation of Akt without influencing p-S473, combination of TNP (10 μM) and SB216763 (1 μM) virtually abolishes adipogenic differentiation of NIH3T3-L1 cells; ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway, also suppresses neutrophil-mediated pulmonary damage in bacterial pneumonia.

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