UC-514321|UC514321

Cas No.:	299420-83-0
Chemical Name:	UC-514321
Synonyms:	UC-514321;NSC368258;Oprea1_747400;6-[(3,5-ditert-butyl-4-hydroxyphenyl)-morpholin-4-ylmethyl]-1,3-benzodioxol-5-ol;1, 6-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl](4-morpholinyl)methyl];1, 6-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-4-morpholinylmethyl]-;SCHEMBL20548110;DA-58854;299420-83-0;6-((3,5-Di-tert-butyl-4-hydroxyphenyl)(morpholino)methyl)benzo[d][1,3]dioxol-5-ol;HY-120395;G12619;MS-27946;AKOS040740951;CS-0077866;6-[(3,5-di-tert-butyl-4-hydroxyphenyl)(morpholin-4-yl)methyl]-2H-1,3-benzodioxol-5-ol;NSC-368258
SMILES:	O1CCN(CC1)C(C1=C(C=C2C(=C1)OCO2)O)C1C=C(C(=C(C=1)C(C)(C)C)O)C(C)(C)C
Formula:	C₂₆H₃₅NO₅
M.Wt:	441.559808015823
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

UC-514321 is a more effective analog of NSC-370284 that directly binds to STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo; shows no inhibitory effect on the viability of TET1-low AML (i.e., NB4) cells, function as TET1-transcription inhibitor in TET1-high AMLs and the anti-leukemic effects are TET1-dependent.

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