UU-T03|UU-T 03|CAS 1586007-00-2|DC Chemicals

Cas No.:	1586007-00-2
Chemical Name:	5-ethyl 1-methyl ((S)-2-((S)-2-(2-(5-chloro-1H-indol-2-yl)acetamido)-3-(naphthalen-2-yl)propanamido)-4-ethoxy-4-oxobutanoyl)-L-glutamate
Synonyms:	UU-T 03
SMILES:	C(C)(O)(=O)[C@H](CCC(CC)(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CC1=CC2=C(C=CC(Cl)=C2)N1)CC1=CC=C2C(C=CC=C2)=C1)CC(OCC)=O
Formula:	C₃₇H₄₁ClN₄O₉
M.Wt:	721.204
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	1. Huang Z, et al. ACS Chem Biol. 2014 Jan 17;9(1):193-201.

Description:	UU-T03 is the ethyl ester derivative of UU-T02, which is a potent, selective inhibitor of β-catenin/Tcf4 interaction with Ki of 1.36 uM; exhibits growth inhibition of SW480 cells with IC50 of 10.77 uM; downregulates the transcription of AXIN2, LGR5, cyclin D1, and c-Myc in dose-dependent manners in SW480 cells.
References:	References 1. Huang Z, et al. ACS Chem Biol. 2014 Jan 17;9(1):193-201. View Related Products by Target Beta-catenin

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