VU 0465350|CAS 1414843-61-0;VU5350|DC Chemicals

Cas No.:	1414843-61-0
Chemical Name:	7-(4-isopropoxyphenyl)-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyridine
Synonyms:	VU0465350;VU5350;VU 5350;VU 0465350;VU0465350;VU-0465350
SMILES:	C12=NC=C(C3=CNN=C3)N1C=CC(C1=CC=C(OC(C)C)C=C1)=C2
Formula:	C₁₉H₁₈N₄O
M.Wt:	318.38
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	1. Tsugawa D, et al. J Pharmacol Exp Ther. 2014 Dec;351(3):549-58.

Description:	A potent, specific BMP receptor activin receptor-like kinase 3 (ALK3) antaognist with Ki of 92.3 nM; shows no activity for ALK2/4/5, also shows affinity for TGFBR2, VEGFR2 and AMPK; blocks SMAD phosphorylation in vitro and in vivo, and enhances liver regeneration after partial hepatectomy.
References:	References 1. Tsugawa D, et al. J Pharmacol Exp Ther. 2014 Dec;351(3):549-58. View Related Products by Target TGF beta Receptor (TGFBR)

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