XE-991 |CAS 122955-42-4|DC Chemicals

Cas No.:	122955-42-4
Chemical Name:	XE991 free base
Synonyms:	9(10H)-Anthracenone,10,10-bis(4-pyridinylmethyl)-;XE 991 DIHYDROCHLORIDE;10,10-bis(pyridin-4-ylmethyl)anthracen-9-one,dihydrochloride;10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone;XE 991;XE9912HCl;10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE;AKOS024456903;AKOS024456903;HB1090;HB1090;10,10-bis(pyridin-4-ylmethyl)anthracen-9(10H)-one dihydrochloride;10,10-bis(pyridin-4-ylmethyl)anthracen-9(10H)-one dihydrochloride;E77156;E77156;FT-0723674;FT-0723674;XEA95513;XEA95513;xe-991 dihydrochloride;xe-991 dihydrochloride;J-004876;J-004876;10,10-bis(pyridin-4-ylmethyl)anthracen-9-one;dihydrochloride;10,10-bis(pyridin-4-ylmethyl)anthracen-9-one;dihydrochloride;DTXSID60662764;DTXSID60662764;122955-42-4;122955-42-4;XE991 Dihydrochloride;XE991 Dihydrochloride;BS-51971;BS-51971;SR-01000597960;SR-01000597960;XE991 HCl;XE991 HCl;CS-0029210;XE-991 2HCl;CS-0029210;HY-108577;XE-991 2HCl;10,10-Bis[(pyridin-4-yl)methyl]anthracen-9(10H)-one--hydrogen chloride (1/2);HY-108577;C26H20N2O.2HCl;10,10-Bis[(pyridin-4-yl)methyl]anthracen-9(10H)-one--hydrogen chloride (1/2);XE991Dihydrochloride;C26H20N2O.2HCl;122955-13-9;XE991Dihydrochloride;s2967;122955-13-9;SR-01000597960-1;s2967;XE 991 dihydrochloride;SR-01000597960-1;XE 991 dihydrochloride
SMILES:	N1C=CC(CC2(CC3C=CN=CC=3)C3C(=CC=CC=3)C(=O)C3=C2C=CC=C3)=CC=1
Formula:	C₂₆H₂₀N₂O
M.Wt:	376.459
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

XE-991 is a potent, selective and orally active blocker of voltage-gated potassium channels Kv7 (KCNQ) that blocks KCNQ1, KCNQ2 and KCNQ2+KCNQ3 with Kd of 0.78, 0.7 and 0.6 uM, respectively; displays 14-fold less potency for KCNQ1+minK current with Kd of 11 uM, enhances hippocampal ACh release from rat brain slices (EC50=490 nM) and is a cognitive enhancer in vivo.Alzheimer DiseaseDiscontinued

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