Ogerin|cas 1309198-71-7|DC Chemicals

Cas No.:	1309198-71-7
Chemical Name:	2-[4-Amino-6-[(phenylmethyl)amino]-1,3,5-triazin-2-yl]benzenemethanol
SMILES:	NC1N=C(NCC2C=CC=CC=2)N=C(C2C=CC=CC=2CO)N=1
Formula:	C₁₇H₁₇N₅O
M.Wt:	307.349782705307
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Ogerin is a selective GPR68 positive allosteric modulator, with a pEC50 of 6.83. Ogerin shows inverse agonist and antagonist activity (Ki, 220 nM) at A2A receptoor and weak antagonist activity (Ki, 736 nM) at 5-HT2B receptor. Ogerin blocks recall in fear conditioning in mice[1].
Target:	pEC50: 6.83 (GPR68)[1] Ki: 220 nM (A2A receptoor), 736 nM (5-HT2B receptor)[1]
References:	[1]. Huang XP, et al. Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65. Nature. 2015 Nov 26;527(7579):477-83.

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