TRPM4 inhibitor 5|cas 351424-20-9|DC Chemicals

Cas No.:	351424-20-9
Chemical Name:	4-Chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]benzoic acid
Synonyms:	TRPM4-IN-5;4-chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]benzoic acid;4-Chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid;CBMicro_024322;Oprea1_449670;GTPL10038;BDBM50526038;STK156559;compound 5 [PMID: 29579323];4-chloro-2-(2-(2-chlorophenoxy)acetamido) benzoic acid;4-chloro-2-{[(2-chlorophenoxy)acetyl]amino}benzoic acid;TRPM4-IN-1
SMILES:	ClC1C([H])=C([H])C(C(=O)O[H])=C(C=1[H])N([H])C(C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1Cl)=O
Formula:	C₁₅H₁₁Cl₂NO₄
M.Wt:	340.1581
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	TRPM4 inhibitor 5 is a potent and selective inhibitor of TRPM4 with IC50 of 1.5 uM (Na+ influx); selectively inhibits TRPM4 overexpressed in HEK293 cells (IC50=1.8 uM) using classical patch-clamp electrophysiology recordings, shows no significant effect on the TRPM5 current, as well as other TRP family members including TRPM7, TRPM8, TRPV1 and TRPV6.
References:	References 1. Ozhathil LC, et al. Br J Pharmacol. 2018 Jun;175(12):2504-2519. View Related Products by Target TRP Channel

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